Leukocytosis can occur acutely and often transiently or chronically in response to an inflammatory stressor/cytokine cascade or as part of an autonomous myeloproliferative neoplasm. Neutrophilia is the most common presentation, but clinicians should be aware of the other cell lines that can be involved in acute and chronic presentations. A detailed history, physical examination, medication reconciliation, full evaluation of a CBC with differential, and comparison to prior CBCs can help clinicians elucidate the underlying cause of leukocytosis and guide appropriate treatment.
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